The clinical sites collected real-time information on the timing and amounts of blood product infusions as well as colloids and crystalloids, vital signs, initial diagnostic and clinical laboratory tests, life saving interventions and other clinical care data. PROMMTT was a multisite prospective observational study of severely injured transfused trauma patients. This report describes the experience of the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study Data Coordination Center in designing and coordinating a study to examine transfusion practices at ten Level 1 trauma centers in the US. Transfusion practices differ among hospitals and it is unknown which transfusion practices improve survival. Rahbar, Mohammad H Fox, Erin E del Junco, Deborah J Cotton, Bryan A Podbielski, Jeanette M Matijevic, Nena Cohen, Mitchell J Schreiber, Martin A Zhang, Jiajie Mirhaji, Parsa Duran, Sarah J Reynolds, Robert J Benjamin-Garner, Ruby Holcomb, John BĮarly death due to hemorrhage is a major consequence of traumatic injury. PMID:22001613Ĭoordination and management of multicenter clinical studies in trauma: Experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study. The observational data collected from this study will be an invaluable resource for research in trauma surgery and it will guide the design and conduct of future randomized trials. Support from the Department of Defense and collaborative expertise from the ten participating centers helped to demonstrate the feasibility of prospective trauma transfusion studies. Conclusion PROMMTT is the first multisite study to collect real-time prospective data on trauma patients requiring transfusion. A total of 297 massive transfusions were observed over the course of the study at a combined rate of 5.0 massive transfusion patients/week. Results Between July 2009 and October 2010, PROMMTT screened 12,561 trauma admissions and enrolled 1,245 patients who received one or more blood transfusions within 6 hours of ED admission. ![]() Methods PROMMTT was a multisite prospective observational study of severely injured transfused trauma patients. ![]() This report describes the experience of the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study Data Coordination Center in designing and coordinating a study to examine transfusion practices at ten Level 1 trauma centers in the U.S. Benjamin-Garner, Ruby Holcomb, John B.Īim Early death due to hemorrhage is a major consequence of traumatic injury. ![]() Zhang, Jiajie Mirhaji, Parsa Duran, Sarah Reynolds, Robert J. Coordination and management of multicenter clinical studies in trauma: Experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study
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